反应详情

温度

40 °C

To a solution of N-benzyl-O-benzyl-N2-Boc-D-serinamide (3 g) and dichloromethane (15 mL), trifluoroacetic acid (15 mL) was added. The solution was stirred for 2 hours at 40° C. for completion of reaction. The solution was concentrated under vacuum to remove solvents and subsequently water was added. The aqueous layer was basified to pH 8-10 with 5% sodium hydroxide. The aqueous layer was extracted with ethyl acetate and the combined organic layer was washed with brine solution. Organic layer was concentrated under vacuum to obtain an oily residue solidify by n-Hexane to give 1.55 g of N-benzyl-O-benzyl-D-serinamide.

1. concentrationThe solution was concentrated under vacuum
2. customto remove solvents and subsequently water
3. additionwas added
4. extractionThe aqueous layer was extracted with ethyl acetate
5. washthe combined organic layer was washed with brine solution
6. concentrationOrganic layer was concentrated under vacuum
7. customto obtain an oily residue solidify by n-Hexane