反应详情

温度

80 °C

To 1,1-dimethylethyl (2S)-2-methyl-4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylate (D1) (15 g, 44.8 mol) in MeOH (150 mL) and water (150 mL) at 80° C. was added ammonium chloride (11.9 g, 0.224 mol) and iron powder (7.5 g, 0.134 mol) with vigorous stirring. The reaction was stirred at 80° C. for 2 h then filtered through Celite®while still hot and the filter cake was washed with further DCM. The filtrate layers were separated and the aqueous layer was washed with DCM (×3). The DCM layers were combined, dried (Na2SO4) and concentrated to give the crude product which was purified by column chromatography. Elution with 20-70% EtOAc/petroleum ether gave the title compound as a white solid (9.46 g).

1. filtrationthen filtered through Celite®while still hot
2. washthe filter cake was washed with further DCM
3. customThe filtrate layers were separated
4. washthe aqueous layer was washed with DCM (×3)
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated
7. customto give the crude product which
8. customwas purified by column chromatography
9. washElution with 20-70% EtOAc/petroleum ether