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HRID53477

反应详情

EQUATION

反应方程式

HRID 53477 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：O=C(CCc1ccc(O)cc1)ON1C(=O)CCC1=O
HCID99557

N-Succinimidyl-3-(4-hydroxyphenyl)propionate

C13H13NO5

结构：Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](N)[C@H]1O
HCID22871861

Adenosine 5′-(tetrahydrogen triphosphate), 3′-amino-3′-deoxy-

C10H17N6O12P3

PRODUCTS

生成物

1
结构：Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](NC(=O)CCc2ccc(O)cc2)[C@H]1O
HCID22871859

未命名化合物

收率 41%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

3'-Amino-3'-deoxyadenosine 5'-triphosphate (6 mg, 11 mmol) and potassium carbonate (7.2 mg, 55 mmol.) were dissolved in 0.8 ml of water. 3-(4-Hydroxyphenyl) propionic acid N-hydroxysuccinimide ester (27 mg, 0.1 mmol) in 0.4 ml of DMSO was added at room temperature, and the mixture was stirred for 24 hours at room temperature. The product was purified by the procedure described for 3'-acetylamino-3'-deoxyadenosine 5'-triphosphate (above); t=14 min (4.3 mg obtained, 41% yield). UV: lmax =259 nm. High resolution MS for C19H24N6O14P3 : calcd. 653.0563, found 653.0596 (MH3-).

WORKUP

后处理

  1. customThe product was purified by the procedure
  2. customt=14 min (4.3 mg obtained, 41% yield)