tert-Butyl methylcarbamate → 1,1-Dimethylethyl (4-formyl-3-methylphenyl)methylcarbamate

HRID 534773Notes

Reaction equation

HRID 534773 reaction equation
Br[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([CH3:10])[CH:3]=1.[CH3:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16]>>[CH:6]([C:5]1[CH:8]=[CH:9][C:2]([CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[CH:3][C:4]=1[CH3:10])=[O:7]

Participants

3

Reactant 2

HCID 527635tert-Butyl methylcarbamateHCID 135551504-Bromo-2-methylbenzaldehyde

Product 1

HCID 866181121,1-Dimethylethyl (4-formyl-3-methylphenyl)methylcarbamate

Procedure

The title compound was prepared from crude 4-bromo-2-methylbenzaldehyde (D91) and 1,1-dimethylethyl methylcarbamate (D83) using a method similar to that described for D84 in Description 84. δH (CDCl3, 400 MHz) 10.20 (1H, s), 7.76 (1H, d), 7.28 (1H, dd), 7.19 (1H, d), 3.31 (3H, s), 2.66 (3H, s), 1.49 (9H, s).

Sources & evidence

ORD record
ord-a4151cb120db4f1fb6a9f1696b683330
Source dataset
uspto-grants-2014_10
Patent number
US08853218B2

Reaction notes

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