Hydrochloric Acid → HCID 42260557, compound

Participants

Reaction Steps

To a stirred solution of methyl 5-oxo-1-phenylprolinate (3.50 g, 15.96 mmol) in methanol (200 mL) was added 1 M NaOH solution (40 mL). After being stirred at room temperature for 2 h, the reaction mixture was acidified with 1 M HCl solution and the mixture was concentrated under reduced pressure. The resulting residue was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting light yellow solid was triturated with hexane to give the title compound (2.47 g, 75%) as a light yellow solid.

Provenance & Evidence