反应详情

To a stirred solution of methyl 5-oxo-1-phenylprolinate (3.50 g, 15.96 mmol) in methanol (200 mL) was added 1 M NaOH solution (40 mL). After being stirred at room temperature for 2 h, the reaction mixture was acidified with 1 M HCl solution and the mixture was concentrated under reduced pressure. The resulting residue was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting light yellow solid was triturated with hexane to give the title compound (2.47 g, 75%) as a light yellow solid.

1. concentrationthe mixture was concentrated under reduced pressure
2. customThe resulting residue was partitioned between ethyl acetate and water
3. washThe organic layer was washed with brine
4. dry with materialdried over anhydrous magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure
7. customThe resulting light yellow solid was triturated with hexane