(3-Chloro-5-(trifluoromethyl)phenyl)methanol → [3-Bromo-5-(trifluoromethyl)phenyl]methanol

HRID 534845Notes

Reaction equation

HRID 534845 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1)[C:5](OC)=[O:6].ClC1C=C(CO)C=C(C(F)(F)F)C=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:5][OH:6])[CH:9]=[C:10]([C:12]([F:14])([F:15])[F:13])[CH:11]=1

Participants

3

Reactant 2

HCID 3857254(3-Chloro-5-(trifluoromethyl)phenyl)methanolHCID 18942156Methyl 3-bromo-5-(trifluoromethyl)benzoate

Product 1

HCID 29919767[3-Bromo-5-(trifluoromethyl)phenyl]methanolYield 35%

Procedure

The title compound was prepared from methyl 3-bromo-5-(trifluoromethyl)benzoate (Reference Example 37) by a procedure similar to the one described for (3-chloro-5-(trifluoromethyl)phenyl)methanol (Reference Example 30) to provide (3-bromo-5-(trifluoromethyl)phenyl)methanol (7.42 g, 35% (2 steps)) as a yellow oil.

Sources & evidence

ORD record
ord-e6c46743bfe84d0ca0ba5b422a1fe056
Source dataset
uspto-grants-2014_10
Patent number
US08853215B2

Reaction notes

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