Methyl 3-(4-(3-bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate → 3-(4-(3-Bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid

HRID 534860Notes

Reaction equation

HRID 534860 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:12]2[N:13]=[C:14]([CH2:17][CH2:18][C:19]([O:21]C)=[O:20])[O:15][CH:16]=2)[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.ClC1C=C(C2N=C(CCC(O)=O)OC=2)C=C(C(F)(F)F)C=1>>[Br:1][C:2]1[CH:3]=[C:4]([C:12]2[N:13]=[C:14]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[O:15][CH:16]=2)[CH:5]=[C:6]([C:8]([F:10])([F:9])[F:11])[CH:7]=1

Participants

3

Reactant 2

HCID 66750877Methyl 3-(4-(3-bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoateHCID 667511183-(4-(3-Chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid

Product 1

HCID 667508933-(4-(3-Bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acidYield 85%

Procedure

The title compound was prepared from methyl 3-(4-(3-bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate (Reference Example 44) by a procedure similar to the one described for 3-(4-(3-chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid (Reference Example 52) to provide 3-(4-(3-bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid (0.316 g, 85%) as an off-white powder.

Sources & evidence

ORD record
ord-60d4b49ace2343a3abea3a6549bdca8b
Source dataset
uspto-grants-2014_10
Patent number
US08853215B2

Reaction notes

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