HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(4-(3-bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate → 3-(4-(3-Bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(4-(3-bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate | HCID 66750877 | — |
| Reactant | 3-(4-(3-Chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid | HCID 66751118 | — |
| Product | 3-(4-(3-Bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid | HCID 66750893 | 85% |
Reaction Steps
The title compound was prepared from methyl 3-(4-(3-bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate (Reference Example 44) by a procedure similar to the one described for 3-(4-(3-chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid (Reference Example 52) to provide 3-(4-(3-bromo-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid (0.316 g, 85%) as an off-white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853215B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-60d4b49ace2343a3abea3a6549bdca8b |
| Source note | uspto-grants-2014_10 |