Methyl 3-(4-(3-isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate → 3-(4-(3-Isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid

HRID 534865Notes

Reaction equation

HRID 534865 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([C:14]2[N:15]=[C:16]([CH2:19][CH2:20][C:21]([O:23]C)=[O:22])[O:17][CH:18]=2)[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1)([CH3:3])[CH3:2].ClC1C=C(C2N=C(CCC(O)=O)OC=2)C=C(C(F)(F)F)C=1>>[CH:1]([C:4]1[CH:5]=[C:6]([C:14]2[N:15]=[C:16]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])[O:17][CH:18]=2)[CH:7]=[C:8]([C:10]([F:12])([F:13])[F:11])[CH:9]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 66750855Methyl 3-(4-(3-isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoateHCID 667511183-(4-(3-Chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid

Product 1

HCID 667508763-(4-(3-Isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acidYield 76%

Procedure

The title compound was prepared from methyl 3-(4-(3-isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate (Reference Example 50) by a procedure similar to the one described for 3-(4-(3-chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid (Reference example 52) to provide 3-(4-(3-isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid (0.132 g, 76%) as a white solid.

Sources & evidence

ORD record
ord-928d823ab5b748f7abb2953b1ae05c6d
Source dataset
uspto-grants-2014_10
Patent number
US08853215B2

Reaction notes

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