HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(4-(3-isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate → 3-(4-(3-Isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(4-(3-isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate | HCID 66750855 | — |
| Reactant | 3-(4-(3-Chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid | HCID 66751118 | — |
| Product | 3-(4-(3-Isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid | HCID 66750876 | 76% |
Reaction Steps
The title compound was prepared from methyl 3-(4-(3-isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoate (Reference Example 50) by a procedure similar to the one described for 3-(4-(3-chloro-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid (Reference example 52) to provide 3-(4-(3-isopropyl-5-(trifluoromethyl)phenyl)oxazol-2-yl)propanoic acid (0.132 g, 76%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853215B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-928d823ab5b748f7abb2953b1ae05c6d |
| Source note | uspto-grants-2014_10 |