Hydrochloric Acid → HCID 66792832, compound

Participants

Reaction Steps

A mixture of methyl (4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)acetate obtained in Example 22 (1.11 g), 1 M sodium hydroxide solution (12 mL), methanol (50 mL), and tetrahydrofuran (50 mL) was stirred at room temperature for 3 h. 1 M hydrochloric acid solution was added to the reaction solution, and the solvent was evaporated under reduced pressure to afford crystals. Crystals were washed with water, diethyl ether and dried under reduced pressure to provide the title compound (1.05 g, 98%) as crystals.

Provenance & Evidence