Hydrochloric Acid → HCID 66792832, compound

HRID 534890Notes

Reaction equation

HRID 534890 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][N:14]([C:17]([C:19]2[CH:30]=[CH:29][C:22]([O:23][CH2:24][C:25]([O:27]C)=[O:26])=[CH:21][CH:20]=2)=[O:18])[CH2:13][CH2:12]1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].CO.Cl>O1CCCC1>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:12][CH2:13][N:14]([C:17]([C:19]2[CH:20]=[CH:21][C:22]([O:23][CH2:24][C:25]([OH:27])=[O:26])=[CH:29][CH:30]=2)=[O:18])[CH2:15][CH2:16]1)([CH3:4])([CH3:2])[CH3:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 66751264HCID 66751264, compound

Product 1

HCID 66792832HCID 66792832, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of methyl (4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)acetate obtained in Example 22 (1.11 g), 1 M sodium hydroxide solution (12 mL), methanol (50 mL), and tetrahydrofuran (50 mL) was stirred at room temperature for 3 h. 1 M hydrochloric acid solution was added to the reaction solution, and the solvent was evaporated under reduced pressure to afford crystals. Crystals were washed with water, diethyl ether and dried under reduced pressure to provide the title compound (1.05 g, 98%) as crystals.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customto afford crystals
  3. washCrystals were washed with water, diethyl ether
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-2eaa3c8dffef4efd97f701ef61950c44
Source dataset
uspto-grants-2014_10
Patent number
US08853215B2

Reaction notes

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