Hydrogen chloride-ethyl acetate → HCID 66751186, compound

HRID 534974Notes

Reaction equation

HRID 534974 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][N:14]([C:17](=[O:34])[C:18]([NH:20][CH:21]2[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]2)=[O:19])[CH2:13][CH2:12]1)([CH3:4])([CH3:3])[CH3:2].[ClH:35].CCOC(C)=O>>[ClH:35].[ClH:35].[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:12][CH2:13][N:14]([C:17](=[O:34])[C:18]([NH:20][CH:21]2[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]2)=[O:19])[CH2:15][CH2:16]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66792801HCID 66792801, compound

Product 1

HCID 66751186HCID 66751186, compound

Procedure

A solution of tert-butyl 4-({[4-(2-tert-butylphenyl)piperazin-1-yl](oxo)acetyl}amino)piperidine-1-carboxylate (Example 181, 2.5 g, 5.29 mmol) in 4 M HCl-EtOAc solution (20 mL) was stirred at room temperature for 3 h. The reaction mixture was concentrated under reduced pressure to give the title compound (2.94 g) as a yellow solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d88bb2dbb4c24df0b6c5183ed19983e9
Source dataset
uspto-grants-2014_10
Patent number
US08853215B2

Reaction notes

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