反应详情

A mixture of 1-{[5-(benzyloxy)-1-methyl-1H-pyrazol-3-yl]carbonyl}-4-(2-tert-butylphenyl)piperazine (1.75 g), and palladium-carbon (500 mg) in methanol (150 mL) was stirred under hydrogen atmosphere (5 atm). The mixture was filtered and concentrated under reduced pressure to purify the residue by silica gel column chromatography (ethyl acetate/methanol 100:0 to 90:10). Solvent was removed to obtain a solid (650 mg, 56%). LC/MS; ESI(+) m/z: 343 (M+H)+.

1. filtrationThe mixture was filtered
2. concentrationconcentrated under reduced pressure
3. customto purify the residue by silica gel column chromatography (ethyl acetate/methanol 100:0 to 90:10)
4. customSolvent was removed