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HRID535107

反应详情

EQUATION

反应方程式

HRID 535107 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)Cl
HCID6367

Acetyl chloride

C2H3ClO

结构：CN1CCOCC1
HCID7972

4-Methylmorpholine

C5H11NO

结构：COC(=O)[C@H]1C[C@H](OC2CCNCC2)CC[C@@H]1C(=O)OC(C)(C)C.Cl
HCID86621493

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@H]1C[C@H](OC2CCN(C(C)=O)CC2)CC[C@@H]1C(=O)OC(C)(C)C
HCID86598267

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

2 次

PROCEDURE

实验过程

A solution of acetyl chloride (24 uL, 0.00033 mol) in 0.5 ml of ACN was added to a solution of 1-tert-butyl 2-methyl (1S,2S,4R)-4-(piperidin-4-yloxy)cyclohexane-1,2-dicarboxylate hydrochloride made above (50 mg, 0.0001 mol) and 4-methylmorpholine (44 uL, 0.00040 mol) in acetonitrile (1.5 mL, 0.029 mol) at 22 Celsius. It was stirred at rt for 30 min, then quenched with Water, extracted with EA, and concentrated to give 1-tert-butyl 2-methyl (1S,2S,4R)-4-[(1-acetylpiperidin-4-yl)oxy]cyclohexane-1,2-dicarboxylate.

WORKUP

后处理

  1. customquenched with Water
  2. extractionextracted with EA
  3. concentrationconcentrated