Hydroxylamine → HCID 87348375, compound

HRID 535108Notes

Reaction equation

HRID 535108 reaction equation
[NH2:1][OH:2].[C:3]([N:6]1[CH2:11][CH2:10][CH:9]([O:12][C@H:13]2[CH2:18][C@H:17]([C:19]([O:21]C)=O)[C@@H:16]([C:23]([N:25]3[CH2:30][CH2:29][N:28]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[CH2:27][CH2:26]3)=[O:24])[CH2:15][CH2:14]2)[CH2:8][CH2:7]1)(=[O:5])[CH3:4]>CO>[C:3]([N:6]1[CH2:7][CH2:8][CH:9]([O:12][C@H:13]2[CH2:18][C@H:17]([C:19]([NH:1][OH:2])=[O:21])[C@@H:16]([C:23]([N:25]3[CH2:30][CH2:29][N:28]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[CH2:27][CH2:26]3)=[O:24])[CH2:15][CH2:14]2)[CH2:10][CH2:11]1)(=[O:5])[CH3:4]

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 67305567HCID 67305567, compound

Product 1

HCID 87348375HCID 87348375, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

1.5 M of H2NOH in MeOH (0.75 ml) was added into a solution of methyl (1S,2S,5R)-5-[(1-acetylpiperidin-4-yl)oxy]-2-[(4-phenylpiperazin-1-yl)carbonyl]cyclohexane-carboxylate (0.1 mmol, 0.0001 mol) in 0.5 ml of MeOH. It was stirred at rt for 2 hrs. It was purified by Prep-HPLC. LCMS: (M+H)+=473.1.

Workup

  1. customIt was purified by Prep-HPLC

Sources & evidence

ORD record
ord-009cae4935c944659fb6c4fd885bb3bf
Source dataset
uspto-grants-2014_10
Patent number
US08853243B2

Reaction notes

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