Acetamide → HCID 131731934, compound

HRID 535213Notes

Reaction equation

[C:1]([NH2:4])(=[O:3])[CH3:2].[NH2:5][C:6]([NH2:8])=[O:7].[S-:9][C:10]#[N:11].[Na+:12]>>[C:1]([NH2:4])(=[O:3])[CH3:2].[NH2:5][C:6]([NH2:8])=[O:7].[S-:9][C:10]#[N:11].[Na+:12]

Participants

Reactant 3

HCID 178Acetamide

HCID 1176Urea

HCID 516871Sodium thiocyanate

Product 1

HCID 131731934HCID 131731934, compoundYield 174.1%

Conditions

Temperature: 30 °C

Procedure

To a round-bottom flask, 3.3 g of purified acetamide, 3.3 g of purified urea and 2 g of NaSCN (sodium thiocyanate) were introduced. The mixture was agitated gradually under nitrogen atmosphere at 30° C. for 5 hours to obtain 8.6 g of acetamide-urea-NaSCN eutectic mixture.

Sources & evidence

ORD record: ord-e12d116557994019af60071235f03252
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08858837B2

Reaction notes

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