Benzoyl chloride → HCID 178522337, compound

HRID 535255Notes

Reaction equation

HRID 535255 reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:10]1[CH:17]=[CH:16][C:14]([NH2:15])=[N:13][C:11]1=[O:12]>N1C=CC=CC=1>[C:1]([NH:15][C:14]1[CH:16]=[CH:17][NH:10][C:11](=[O:12])[N:13]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 178418229Cytosine

Product 1

HCID 178522337HCID 178522337, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Benzoyl chloride (2.3 mL, 20 mmol) was added dropwise over 30 min to a stirred suspension of cytosine (1.1 g, 10 mmol) in dry pyridine, and stirring was continued at room temperature for a further 4 h at room temperature. The reaction was quenched by adding a small amount of methanol. The solid was filtered, washed with EtOH and dried in vacuo to give 1.92 g of the desired product 6 (90%).

Workup

  1. customThe reaction was quenched
  2. additionby adding a small amount of methanol
  3. filtrationThe solid was filtered
  4. washwashed with EtOH
  5. customdried in vacuo

Sources & evidence

ORD record
ord-3daff7950b4f428ea7929011344d06e4
Source dataset
uspto-grants-2014_10
Patent number
US08859490B2

Reaction notes

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