Methyl 3-(4-hydroxyphenyl)hex-4-ynoate → 3-{4-[3-(2-Chloro-4-trifluoromethylphenoxymethyl)oxetan-3-ylmethoxy]phenyl}hex-4-ynoic acid

HRID 535266Notes

Reaction equation

HRID 535266 reaction equation
[Cl:1][C:2]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:3]=1[O:4][CH2:5][C:6]1([CH2:10][OH:11])[CH2:9][O:8][CH2:7]1.O[C:21]1[CH:26]=[CH:25][C:24]([CH:27]([C:33]#[C:34][CH3:35])[CH2:28][C:29]([O:31]C)=[O:30])=[CH:23][CH:22]=1>>[Cl:1][C:2]1[CH:15]=[C:14]([C:16]([F:18])([F:17])[F:19])[CH:13]=[CH:12][C:3]=1[O:4][CH2:5][C:6]1([CH2:10][O:11][C:21]2[CH:26]=[CH:25][C:24]([CH:27]([C:33]#[C:34][CH3:35])[CH2:28][C:29]([OH:31])=[O:30])=[CH:23][CH:22]=2)[CH2:7][O:8][CH2:9]1

Participants

3

Reactant 2

HCID 57835749Methyl 3-(4-hydroxyphenyl)hex-4-ynoateHCID 58031838[3-(2-Chloro-4-trifluoromethylphenoxymethyl)oxetan-3-yl]-methanol

Product 1

HCID 565922053-{4-[3-(2-Chloro-4-trifluoromethylphenoxymethyl)oxetan-3-ylmethoxy]phenyl}hex-4-ynoic acid

Procedure

Analogously to example 1, [3-(2-chloro-4-trifluoromethylphenoxymethyl)oxetan-3-yl]-methanol and methyl 3-(4-hydroxyphenyl)hex-4-ynoate were used to obtain 3-{4-[3-(2-chloro-4-trifluoromethylphenoxymethyl)oxetan-3-ylmethoxy]phenyl}hex-4-ynoic acid.

Sources & evidence

ORD record
ord-df6b871dfb9b4494b2ef1e222030565d
Source dataset
uspto-grants-2014_10
Patent number
US08859494B2

Reaction notes

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