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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 535266Generated: October 30, 2026

Methyl 3-(4-hydroxyphenyl)hex-4-ynoate → 3-{4-[3-(2-Chloro-4-trifluoromethylphenoxymethyl)oxetan-3-ylmethoxy]phenyl}hex-4-ynoic acid

https://huagongshe.com/reaction/535266

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 3-(4-hydroxyphenyl)hex-4-ynoateHCID 57835749—
Reactant[3-(2-Chloro-4-trifluoromethylphenoxymethyl)oxetan-3-yl]-methanolHCID 58031838—
Product3-{4-[3-(2-Chloro-4-trifluoromethylphenoxymethyl)oxetan-3-ylmethoxy]phenyl}hex-4-ynoic acidHCID 56592205—

Reaction Steps

Analogously to example 1, [3-(2-chloro-4-trifluoromethylphenoxymethyl)oxetan-3-yl]-methanol and methyl 3-(4-hydroxyphenyl)hex-4-ynoate were used to obtain 3-{4-[3-(2-chloro-4-trifluoromethylphenoxymethyl)oxetan-3-ylmethoxy]phenyl}hex-4-ynoic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08859494B2
Source datasetuspto-grants-2014_10
ORD IDord-df6b871dfb9b4494b2ef1e222030565d
Source noteuspto-grants-2014_10