Phenol, 3-(1,1-dimethylethyl)- → 3-{4-[1-(3-Tert-butylphenoxymethyl)cyclobutylmethoxy]phenyl}hex-4-ynoic acid

HRID 535267Notes

Reaction equation

HRID 535267 reaction equation
[C:1]1([CH2:7][OH:8])([CH2:5][OH:6])[CH2:4][CH2:3][CH2:2]1.[C:9]([C:13]1[CH:14]=[C:15](O)[CH:16]=[CH:17][CH:18]=1)([CH3:12])([CH3:11])[CH3:10].O[C:21]1[CH:26]=[CH:25][C:24]([CH:27]([C:33]#[C:34][CH3:35])[CH2:28][C:29]([O:31]C)=[O:30])=[CH:23][CH:22]=1>>[C:9]([C:13]1[CH:14]=[C:15]([CH:16]=[CH:17][CH:18]=1)[O:6][CH2:5][C:1]1([CH2:7][O:8][C:21]2[CH:26]=[CH:25][C:24]([CH:27]([C:33]#[C:34][CH3:35])[CH2:28][C:29]([OH:31])=[O:30])=[CH:23][CH:22]=2)[CH2:4][CH2:3][CH2:2]1)([CH3:12])([CH3:11])[CH3:10]

Participants

4

Reactant 3

HCID 11450Phenol, 3-(1,1-dimethylethyl)-HCID 4498243Cyclobutane-1,1-diyldimethanolHCID 57835749Methyl 3-(4-hydroxyphenyl)hex-4-ynoate

Product 1

HCID 565922853-{4-[1-(3-Tert-butylphenoxymethyl)cyclobutylmethoxy]phenyl}hex-4-ynoic acid

Procedure

Analogously to example 1, cyclobutane-1,1-diyldimethanol, 3-tert-butylphenol and methyl 3-(4-hydroxyphenyl)hex-4-ynoate were used to obtain 3-{4-[1-(3-tert-butylphenoxymethyl)cyclobutylmethoxy]phenyl}hex-4-ynoic acid.

Sources & evidence

ORD record
ord-c178362e27ae4ea39de9bce9de75b92c
Source dataset
uspto-grants-2014_10
Patent number
US08859494B2

Reaction notes

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