M-Cresol → 3-[4-(1-m-Tolyloxymethylcyclobutylmethoxy)phenyl]hex-4-ynoic acid

HRID 535269Notes

Reaction equation

HRID 535269 reaction equation
[C:1]1([CH2:7][OH:8])([CH2:5][OH:6])[CH2:4][CH2:3][CH2:2]1.[CH3:9][C:10]1[CH:11]=[C:12](O)[CH:13]=[CH:14][CH:15]=1.O[C:18]1[CH:23]=[CH:22][C:21]([CH:24]([C:30]#[C:31][CH3:32])[CH2:25][C:26]([O:28]C)=[O:27])=[CH:20][CH:19]=1>>[C:10]1([CH3:9])[CH:11]=[CH:12][CH:13]=[C:14]([O:6][CH2:5][C:1]2([CH2:7][O:8][C:18]3[CH:23]=[CH:22][C:21]([CH:24]([C:30]#[C:31][CH3:32])[CH2:25][C:26]([OH:28])=[O:27])=[CH:20][CH:19]=3)[CH2:4][CH2:3][CH2:2]2)[CH:15]=1

Participants

4

Reactant 3

HCID 342M-CresolHCID 4498243Cyclobutane-1,1-diyldimethanolHCID 57835749Methyl 3-(4-hydroxyphenyl)hex-4-ynoate

Product 1

HCID 565922873-[4-(1-m-Tolyloxymethylcyclobutylmethoxy)phenyl]hex-4-ynoic acid

Procedure

Analogously to example 1, cyclobutane-1,1-diyldimethanol, 3-methylphenol and methyl 3-(4-hydroxyphenyl)hex-4-ynoate were used to obtain 3-[4-(1-m-tolyloxymethylcyclobutylmethoxy)phenyl]hex-4-ynoic acid.

Sources & evidence

ORD record
ord-2b834d2433634f9a818af978ea34e587
Source dataset
uspto-grants-2014_10
Patent number
US08859494B2

Reaction notes

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