反应详情

Hydrobromic acid (48%, 2 ml) was added to a solution of 5,11-dihydro-11-ethyl-2-methoxy-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (0.3 g) in acetic acid (2 ml), and the resulting mixture was rapidly heated to reflux for 5 min. The reaction mixture was quenched with 10% sodium hydroxide (10 ml) and the product was extracted with ethyl acetate, dried (anhydrous magnesium sulfate) and concentrated to give a solid which was recrystallized from ethyl acetate to give 0.08 g of product, m.p. 215°-218° C.

1. temperaturethe resulting mixture was rapidly heated
2. temperatureto reflux for 5 min
3. customThe reaction mixture was quenched with 10% sodium hydroxide (10 ml)
4. extractionthe product was extracted with ethyl acetate
5. dry with materialdried (anhydrous magnesium sulfate)
6. concentrationconcentrated
7. customto give a solid which
8. customwas recrystallized from ethyl acetate