2-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborate → HCID 59476966, compound

HRID 535282Notes

Reaction equation

HRID 535282 reaction equation
[C:1]([O:5][C:6](=[O:37])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13](=[O:36])[NH:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][CH2:27][NH:28][C:29](=[O:35])[CH2:30][CH2:31][C:32]([OH:34])=[O:33])([CH3:4])([CH3:3])[CH3:2].[B-](F)(F)(F)F.CN(C(O[N:51]1[C:56](=[O:57])[CH2:55][CH2:54][C:52]1=[O:53])=[N+](C)C)C>>[C:1]([O:5][C:6](=[O:37])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13](=[O:36])[NH:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][CH2:27][NH:28][C:29](=[O:35])[CH2:30][CH2:31][C:32]([O:34][N:51]1[C:56](=[O:57])[CH2:55][CH2:54][C:52]1=[O:53])=[O:33])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 98575222-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborateHCID 59476977HCID 59476977, compound

Product 1

HCID 59476966HCID 59476966, compound

Procedure

7-[3-(2-{2-[3-(3-Carboxypropionylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-heptanoic acid tert-butyl ester (0.78 g, 1.46 mmol) was activated by means of TSTU as described in example 8 step 4. Crude yield 360 mg, LCMS Method 6: Rt 4.40 min; m/z (M+1) 630; Calcd.: 630. The compound was used without further purification.

Workup

  1. customThe compound was used without further purification

Sources & evidence

ORD record
ord-5fe1fbdd023740848e2137ab9ac1889e
Source dataset
uspto-grants-2014_10
Patent number
US08859493B2

Reaction notes

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