Succinic anhydride → HCID 57874358, compound

HRID 535283Notes

Reaction equation

HRID 535283 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][CH2:20][NH2:21])=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:22]1(=[O:28])[O:27][C:25](=[O:26])[CH2:24][CH2:23]1>C1COCC1.C(#N)C>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][CH2:20][NH:21][C:22](=[O:28])[CH2:23][CH2:24][C:25]([OH:27])=[O:26])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 7922Succinic anhydrideHCID 14373549tert-Butyl {3-[4-(3-aminopropoxy)butoxy]propyl}carbamate

Product 1

HCID 57874358HCID 57874358, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 8028TetrahydrofuranSolvent

Procedure

1-(tert-Butoxycarbonylamino)-4,9-dioxa-12-dodecanamine (5.0 g, 16.45 mmol) was dissolved in THF (30 mL), succinic anhydride (1.81 g, 18.1 mmol) in acetonitrile (10 mL) was added and the mixture was heated to 60 C for 4 h, and subsequently stirred at RT overnight.

Workup

  1. temperaturethe mixture was heated to 60 C for 4 h

Sources & evidence

ORD record
ord-d10ff3fe7c0346c389e86257c7e03810
Source dataset
uspto-grants-2014_10
Patent number
US08859493B2

Reaction notes

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