HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethyl}-succinamic acid → 7-(2-{2-[2-(3-Carboxy-propionylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-heptanoic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethyl}-succinamic acid | HCID 57325707 | — |
| Reactant | 1-tert-Butyl 8-(2,5-dioxopyrrolidin-1-yl) octanedioate | HCID 59760896 | — |
| Product | 7-(2-{2-[2-(3-Carboxy-propionylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-heptanoic acid tert-butyl ester | HCID 59476999 | 132.2% |
Reaction Steps
Octanedioic acid tert-butyl ester 2,5-dioxo-pyrrolidin-1-yl ester (1.13 g, 3.45 mmol) and N-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethyl}-succinamic acid (1 g, 2.874 mmol) were reacted as described above. 1.75 g crude product was isolated and used without further purification. LCMS (Method 6): Rt 3.86 min; m/z (M+1) 461; Calcd.: 461.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859493B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-2a07b649065546e887f7a4bcd38c2feb |
| Source note | uspto-grants-2014_10 |