4-Chlorophenylacetyl chloride → HCID 71469053, compound

HRID 535483Notes

Reaction equation

HRID 535483 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:13]=[N:14][C:15]([Cl:18])=[CH:16][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](Cl)=[O:29])=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:13]=[N:14][C:15]([Cl:18])=[CH:16][CH:17]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:19])=[O:29])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 86673556HCID 86673556, compound

Product 1

HCID 71469053HCID 71469053, compound

Procedure

The product of Example 4B was treated with 2-(4-chlorophenyl)acetyl chloride similar to the method described in Example 4C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.76 (s, 1H), 8.65 (dd, J=2.5, 0.8 Hz, 1H), 8.39-8.43 (m, 1H), 8.13 (dd, J=8.2, 2.5 Hz, 1H), 7.86-8.02 (m, 2H), 7.67-7.81 (m, 2H), 7.37-7.44 (m, 4H), 3.71 (s, 2H); MS (ESI+) M/Z 425 (M+H)+.

Sources & evidence

ORD record
ord-d56e730c2e904627be40dbf94d40629f
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

Loading…