3,5-Difluorophenylacetic acid → HCID 70976097, compound

HRID 535491Notes

Reaction equation

HRID 535491 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[S:13][CH:14]=[CH:15][C:16]=2[CH3:17])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[F:19][C:20]1[CH:21]=[C:22]([CH2:27][C:28](O)=[O:29])[CH:23]=[C:24]([F:26])[CH:25]=1>>[F:19][C:20]1[CH:21]=[C:22]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[S:13][CH:14]=[CH:15][C:16]=3[CH3:17])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:29])[CH:23]=[C:24]([F:26])[CH:25]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 70976322HCID 70976322, compound

Product 1

HCID 70976097HCID 70976097, compound

Procedure

The product from Example 14B and 2-(3,5-difluorophenyl)acetic acid was processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.78 (s, 1H), 8.39-8.42 (m, 1H), 7.90-8.05 (m, 2H), 7.73 (d, J=5.1 Hz, 1H), 7.62-7.65 (m, 1H), 7.08-7.22 (m, 4H), 3.77 (s, 2H), 2.10 (s, 3H); MS (APCI) M/Z 412 (M+H)+.

Sources & evidence

ORD record
ord-a1d22093d68144b0a5296772e384124f
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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