3,5-Difluorophenylacetic acid → HCID 70976254, compound

HRID 535494Notes

Reaction equation

HRID 535494 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[F:19][C:20]1[CH:21]=[C:22]([CH2:27][C:28](O)=[O:29])[CH:23]=[C:24]([F:26])[CH:25]=1>>[F:19][C:20]1[CH:21]=[C:22]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:29])[CH:23]=[C:24]([F:26])[CH:25]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 21262530HCID 21262530, compound

Product 1

HCID 70976254HCID 70976254, compound

Procedure

The product from Example 18A and 2-(3,5-difluorophenyl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ 11.83 (s, 1H), 8.78 (ddd, J=4.8, 1.7, 0.9, 1H), 8.46-8.30 (m, 2H), 7.99 (dddd, J=16.4, 15.3, 7.5, 1.6, 3H), 7.80 (dt, J=7.8, 1.0, 1H), 7.59 (ddd, J=7.6, 4.8, 1.1, 1H), 7.23-7.09 (m, 3H), 3.79 (s, 2H); MS (APCI) M/Z 393 (M+H)+.

Sources & evidence

ORD record
ord-3fc2b0908d574559b0e194865539ee2c
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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