Hydrazine hydrate (1:1) → HCID 23153686, compound

HRID 535495Notes

Reaction equation

HRID 535495 reaction equation
[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([C:7]([C:9]2[CH:19]=[CH:18][CH:17]=[CH:16][C:10]=2[C:11](OCC)=[O:12])=O)=[CH:5][N:4]=1.O.[NH2:23][NH2:24]>C(O)C>[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([C:7]2[C:9]3[C:10](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:11](=[O:12])[NH:24][N:23]=2)=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 70976014HCID 70976014, compound

Product 1

HCID 23153686HCID 23153686, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of ethyl 2-(6-methoxynicotinoyl)benzoate (0.496 g, 1.74 mmol) and hydrazine hydrate (0.39 mL, 6.9 mmol) in ethanol (6 mL) was stirred at 80° C. for 2 hours, concentrated, and azeotroped with PhMe to give crude 4-(6-methoxypyridin-3-yl)phthalazin-1(2H)-one, which was used without purification.

Workup

  1. concentrationconcentrated
  2. customazeotroped with PhMe

Sources & evidence

ORD record
ord-d5adcc662f5d4aa0b7086a4cc4f30acc
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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