4-Chlorophenylacetyl chloride → HCID 70976126, compound

HRID 535508Notes

Reaction equation

HRID 535508 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([S:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](Cl)=[O:29])=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([S:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:19])=[O:29])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 70976345HCID 70976345, compound

Product 1

HCID 70976126HCID 70976126, compound

Procedure

The product from Example 57B and 2-(4-chlorophenyl)acetyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ 11.69 (s, 1H), 8.34 (dd, J=7.9, 1.1, 1H), 8.08 (d, J=7.4, 1H), 8.00 (td, J=7.7, 1.5, 1H), 7.94 (td, J=7.6, 1.3, 1H), 7.40 (d, J=8.8, 9H), 3.66 (s, 2H); MS (APCI+) M/Z 422 (M+H)+.

Sources & evidence

ORD record
ord-4bccacea2daf4f36a05b4b027c07a138
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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