3,5-Difluorophenylacetic acid → HCID 70975778, compound

HRID 535509Notes

Reaction equation

HRID 535509 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH:16]([CH3:18])[O:15][CH:14]([CH3:19])[CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:20].[F:21][C:22]1[CH:23]=[C:24]([CH2:29][C:30](O)=[O:31])[CH:25]=[C:26]([F:28])[CH:27]=1>>[F:21][C:22]1[CH:23]=[C:24]([CH2:29][C:30]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:13][CH:14]([CH3:19])[O:15][CH:16]([CH3:18])[CH2:17]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:20])=[O:31])[CH:25]=[C:26]([F:28])[CH:27]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 70975969HCID 70975969, compound

Product 1

HCID 70975778HCID 70975778, compound

Procedure

The product from Example 60A and 2-(3,5-difluorophenyl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.54-11.55 (m, 1H), 8.30-8.34 (m, 1H), 8.01-8.04 (m, 1H), 7.96-8.01 (m, 1H), 7.87-7.92 (m, 1H), 7.11-7.19 (m, 3H), 3.84-3.93 (m, 2H), 3.73 (s, 2H), 3.32-3.36 (buried m, 2H), 2.40-2.47 (m, 2H), 1.12 (d, J=6.2 Hz, 6H); MS (APCI+) M/Z 429 (M+H)+.

Sources & evidence

ORD record
ord-1f43dda483b447779239120c0d543a71
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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