3,5-Difluorophenylacetic acid → HCID 56927667, compound

HRID 535515Notes

Reaction equation

HRID 535515 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:14])=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:21].[F:22][C:23]1[CH:24]=[C:25]([CH2:30][C:31](O)=[O:32])[CH:26]=[C:27]([F:29])[CH:28]=1>>[F:22][C:23]1[CH:24]=[C:25]([CH2:30][C:31]([NH:1][N:2]2[N:11]=[C:10]([S:12]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)(=[O:14])=[O:13])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:21])=[O:32])[CH:26]=[C:27]([F:29])[CH:28]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 70975871HCID 70975871, compound

Product 1

HCID 56927667HCID 56927667, compound

Procedure

The product from Example 68B and 2-(3,5-difluorophenyl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (500 MHz, CDCl3) δ ppm 8.69-8.72 (m, 1H), 8.44-8.47 (m, 1H), 8.31-8.35 (bs, 1H), 8.00-8.06 (m, 2H), 7.93-7.98 (m, 1H), 7.85-7.90 (m, 1H), 7.66-7.70 (m, 1H), 7.55-7.61 (m, 2H), 6.82-6.91 (m, 2H), 6.74-6.81 (m, 1H), 3.69-3.74 (bs, 2H); MS (APCI+) M/Z 456 (M+H)+.

Sources & evidence

ORD record
ord-b6762a5d038e44899ca91ce6beb379a3
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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