4-Chlorophenylacetyl chloride → HCID 70673582, compound

HRID 535516Notes

Reaction equation

HRID 535516 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:14])=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:21].[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30](Cl)=[O:31])=[CH:25][CH:24]=1>>[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30]([NH:1][N:2]2[N:11]=[C:10]([S:12]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)(=[O:14])=[O:13])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:21])=[O:31])=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 70975871HCID 70975871, compound

Product 1

HCID 70673582HCID 70673582, compound

Procedure

The product from Example 68B and (4-chlorophenyl)acetyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (500 MHz, CDCl3) δ ppm 8.67-8.69 (m, 1H), 8.43 (d, J=8.0 Hz, 1H), 8.22-8.24 (bs, 1H), 8.00-8.04 (m, 2H), 7.90-7.97 (m, 1H), 7.82-7.87 (m, 1H), 7.66-7.70 (m, 1H), 7.54-7.58 (m, 2H), 7.33-7.36 (m, 2H), 7.24-7.30 (m, 2H), 3.71-3.74 (bs, 2H); MS (APCI+) M/Z 454 (M+H)+.

Sources & evidence

ORD record
ord-f51157fc3bd2416a9b644ad673535bc5
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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