4-Chlorophenylacetyl chloride → HCID 70976138, compound

HRID 535519Notes

Reaction equation

HRID 535519 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:22].[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][C:31](Cl)=[O:32])=[CH:26][CH:25]=1>>[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][C:31]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:22])=[O:32])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 70976071HCID 70976071, compound

Product 1

HCID 70976138HCID 70976138, compound

Procedure

The product from Example 76B and 2-(4-chlorophenyl)acetyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.80-11.82 (bs, 1H), 8.96-8.99 (m, 1H), 8.40-8.46 (m, 1H), 8.12 (s, 1H), 7.96-8.04 (m, 3H), 7.71-7.79 (m, 1H), 7.36-7.44 (m, 4H), 3.72 (s, 2H); MS (APCI) M/Z 459 (M+H)+.

Sources & evidence

ORD record
ord-a86eb884b296430a9e24b6421c0e0c60
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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