Methanesulfonyl chloride → HCID 70975849, compound

HRID 535521Notes

Reaction equation

HRID 535521 reaction equation
[NH2:1][CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:13])[N:5]([NH:14][C:15](=[O:24])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[N:4]=1.[CH3:25][S:26](Cl)(=[O:28])=[O:27]>>[Cl:23][C:20]1[CH:19]=[CH:18][C:17]([CH2:16][C:15]([NH:14][N:5]2[N:4]=[C:3]([CH2:2][NH:1][S:26]([CH3:25])(=[O:28])=[O:27])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]2=[O:13])=[O:24])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 70976268HCID 70976268, compound

Product 1

HCID 70975849HCID 70975849, compound

Procedure

The product from Example 42 and methanesulfonyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.66-11.72 (m, 1H), 8.31-8.43 (m, 1H), 8.15 (d, J=8.0 Hz, 1H), 7.99-8.06 (m, 1H), 7.89-7.96 (m, 1H), 7.66-7.74 (bs, 1H), 7.36-7.45 (m, 4H), 4.46-4.49 (m, 2H), 3.68 (s, 2H), 2.94 (s, 3H); MS (ESI+) M/Z 421 (M+H)+.

Sources & evidence

ORD record
ord-5a29ee413da34a7e937795a89b3c254e
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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