Phenylacetyl chloride → HCID 70975741, compound

HRID 535525Notes

Reaction equation

[NH2:1][CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:13])[N:5]([NH:14][C:15](=[O:24])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[N:4]=1.[C:25]1([CH2:31][C:32](Cl)=[O:33])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[Cl:23][C:20]1[CH:19]=[CH:18][C:17]([CH2:16][C:15]([NH:14][N:5]2[N:4]=[C:3]([CH2:2][NH:1][C:32](=[O:33])[CH2:31][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]2=[O:13])=[O:24])=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 7679Phenylacetyl chloride

HCID 70976268HCID 70976268, compound

Product 1

HCID 70975741HCID 70975741, compound

Procedure

The product from Example 42 and 2-phenylacetyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (500 MHz, CDCl3) δ ppm 8.42 (d, J=7.8 Hz, 1H), 8.11-8.13 (bs, 1H), 7.83-7.91 (m, 2H), 7.76-7.82 (m, 1H), 7.39 (s, 3H), 7.23-7.35 (buried m, 6H), 6.24-6.30 (bs, 1H), 4.72-4.74 (m, 2H), 3.79-3.80 (bs, 2H), 3.63-3.63 (bs, 2H); MS (ESI−) M/Z 459 (M−H)−.

Sources & evidence

ORD record: ord-80ac2748d98542d1b7a8bae28ed241ae
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08859549B2

Reaction notes

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