3,5-Difluorophenylacetic acid → HCID 70975864, compound

HRID 535529Notes

Reaction equation

HRID 535529 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][S:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[F:19][C:20]1[CH:21]=[C:22]([CH2:27][C:28](O)=[O:29])[CH:23]=[C:24]([F:26])[CH:25]=1>>[F:19][C:20]1[CH:21]=[C:22]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:13][CH2:14][S:15][CH2:16][CH2:17]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:29])[CH:23]=[C:24]([F:26])[CH:25]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 70976237HCID 70976237, compound

Product 1

HCID 70975864HCID 70975864, compound

Procedure

The product from Example 91B and 2-(3,5-difluorophenyl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.55 (s, 1H), 8.30 (d, J=7.9 Hz, 1H), 7.84-8.02 (m, 3H), 7.05-7.19 (m, 3H), 3.73 (s, 2H), 2.83-2.87 (m, 4H); MS (APCI+) M/Z 417 (M+H)+.

Sources & evidence

ORD record
ord-01c202afa9744a3a8a215d5f31eab724
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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