4-Chlorophenylacetyl chloride → HCID 131731941, compound

HRID 535532Notes

Reaction equation

HRID 535532 reaction equation
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([S:13][C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[CH:16][CH:15]=2)=[N:3]1.[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][C:36](Cl)=[O:37])=[CH:31][CH:30]=1>>[C:23]([O:22][C:21](=[O:27])[NH:20][C:17]1[CH:18]=[CH:19][C:14]([S:13][C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[C:11](=[O:12])[N:2]([NH:1][C:36](=[O:37])[CH2:35][C:32]3[CH:33]=[CH:34][C:29]([Cl:28])=[CH:30][CH:31]=3)[N:3]=2)=[CH:15][CH:16]=1)([CH3:24])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 70975898HCID 70975898, compound

Product 1

HCID 131731941HCID 131731941, compound

Procedure

The product from Example 103B and 2-(4-chlorophenyl)acetyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ 10.83-10.76 (m, 1H), 8.30-8.25 (m, 1H), 8.06-7.99 (m, 1H), 7.99-7.93 (m, 1H), 7.93-7.86 (m, 1H), 7.44 (d, J=8.8, 2H), 7.41-7.37 (m, 2H), 7.35-7.31 (m, 4H), 3.53 (s, 2H), 1.32 (s, 9H); MS (APCI+) M/Z 537 (M+H)+.

Sources & evidence

ORD record
ord-6ed11230194a4ef7934a6cd9472d13b2
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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