4-Chlorophenylacetyl chloride → HCID 70976342, compound

HRID 535535Notes

Reaction equation

HRID 535535 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](Cl)=[O:29])=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH2:17]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:19])=[O:29])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 70975780HCID 70975780, compound

Product 1

HCID 70976342HCID 70976342, compound

Procedure

The product from Example 107B and (4-chlorophenyl)acetyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ 11.55 (s, 1H), 9.77 (s, 1H), 8.32 (d, J=7.9, 1H), 8.03-7.97 (m, 2H), 7.96-7.89 (m, 1H), 7.45-7.36 (m, 4H), 3.68 (s, 2H), 3.65-3.50 (m, 4H), 3.08-2.98 (m, 2H), 2.91 (s, 3H), 2.49-2.44 (buried m, 2H); MS (APCI+) M/Z 412 (M+H)+.

Sources & evidence

ORD record
ord-10669021c9b6439f810959120216fbd6
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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