4-Chlorophenylacetyl chloride → HCID 70975846, compound

HRID 535537Notes

Reaction equation

HRID 535537 reaction equation
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:13]([CH3:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[N:3]1.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](Cl)=[O:29])=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([NH:1][N:2]2[C:11](=[O:12])[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[C:4]([CH:13]([CH3:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[N:3]2)=[O:29])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 70975878HCID 70975878, compound

Product 1

HCID 70975846HCID 70975846, compound

Procedure

The product of Example 109B and 2-(4-chlorophenyl)acetyl chloride were processed using a method similar to that described in Example 4C to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ 11.60 (s, 1H), 8.34 (d, J=7.8, 1H), 8.05-7.96 (m, 2H), 7.92 (ddd, J=8.1, 6.1, 2.3, 1H), 7.45-7.35 (m, 4H), 4.52 (q, J=7.1, 1H), 4.12-3.99 (m, 2H), 3.68 (s, 2H), 1.46 (d, 3H), 1.06 (t, 3H); MS (ESI+) M/Z 414 (M+H)+.

Sources & evidence

ORD record
ord-c6c6b1eece274b73be1163a00607eea3
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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