Tert-Butylamine → HCID 70976093, compound

HRID 535545Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][N:12]2[C:21](=[O:22])[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14]([CH2:23][C:24](O)=[O:25])=[N:13]2)=[O:10])=[CH:4][CH:3]=1.[C:27]([NH2:31])([CH3:30])([CH3:29])[CH3:28]>>[C:27]([NH:31][C:24](=[O:25])[CH2:23][C:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:21](=[O:22])[N:12]([NH:11][C:9](=[O:10])[CH2:8][C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:13]=1)([CH3:30])([CH3:29])[CH3:28]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 70976120HCID 70976120, compound

Product 1

HCID 70976093HCID 70976093, compound

Procedure

The product of Example 114 and tert-butylamine were treated using a method similar to that described in Example 112 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ 11.60 (s, 1H), 8.30 (d, J=7.9, 1H), 8.02-7.85 (m, 4H), 7.45-7.37 (m, 4H), 3.78 (s, 2H), 3.67 (s, 2H), 1.25 (s, 9H); MS (ESI−) M/Z 425 (M−H)−.

Sources & evidence

ORD record: ord-27c8bbe3fcfc435dac349ffe28f09d7f
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08859549B2

Reaction notes

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