3,3,3-Trifluoropropionic acid → HCID 70976207, compound

HRID 535557Notes

Reaction equation

HRID 535557 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[F:19][C:20]([F:26])([F:25])[CH2:21][C:22](O)=[O:23]>>[F:19][C:20]([F:26])([F:25])[CH2:21][C:22]([NH:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18])=[O:23]

Participants

3

Reactant 2

HCID 27779723,3,3-Trifluoropropionic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976207HCID 70976207, compound

Procedure

The product of Example 1B and 3,3,3-trifluoropropanoic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.32 (dd, J=7.9, 1.3 Hz, 1H), 8.04 (dd, J=8.1, 1.3 Hz, 1H), 7.98-8.02 (m, 1H), 7.93 (td, J=7.5, 1.3 Hz, 1H), 3.82-3.84 (m, 4H), 3.53-3.60 (m, 2H), 3.09-3.11 (m, 4H); MS (ESI+) M/Z 357 (M+H)+.

Sources & evidence

ORD record
ord-2bf7bd61cebf43d995226a087ae5b352
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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