(2-Nitrophenyl)acetic acid → HCID 70975844, compound

HRID 535563Notes

Reaction equation

HRID 535563 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[N+:19]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[CH2:28][C:29](O)=[O:30])([O-:21])=[O:20]>>[N:12]1([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:18])[N:2]([NH:1][C:29](=[O:30])[CH2:28][C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[N+:19]([O-:21])=[O:20])[N:11]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 77337(2-Nitrophenyl)acetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70975844HCID 70975844, compound

Procedure

The product of Example 1B and 2-(2-nitrophenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/D2O) δ 8.30 (d, J=7.7, 1H), 8.09-7.95 (m, 4H), 7.94-7.87 (m, 1H), 7.73 (dt, J=7.6, 3.8, 1H), 7.63 (d, J=6.7, 1H), 7.59 (dd, J=11.2, 4.4, 1H), 4.13 (s, 2H), 3.86-3.79 (m, 4H), 3.14-3.04 (m, 4H); MS (ESI+) M/Z 410 (M+H)+.

Sources & evidence

ORD record
ord-6e7077df109049be9933d762685f95c4
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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