(3-Methoxyphenyl)acetic acid → HCID 70976130, compound

HRID 535567Notes

Reaction equation

HRID 535567 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH2:27][C:28](O)=[O:29])[CH:24]=[CH:25][CH:26]=1>>[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:29])[CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 15719(3-Methoxyphenyl)acetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976130HCID 70976130, compound

Procedure

The product of Example 1B and 2-(3-methoxyphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (dd, J=7.9, 1.3 Hz, 1H), 7.97-8.05 (m, 2H), 7.91 (td, J=7.5, 1.3 Hz, 1H), 7.27 (t, J=7.8 Hz, 1H), 6.98-6.99 (m, 1H), 6.96 (d, J=7.6 Hz, 1H), 6.86 (dd, J=8.2, 2.6 Hz, 1H), 3.81-3.83 (m, 4H), 3.77 (s, 3H), 3.63 (s, 2H), 3.03-3.13 (m, 4H); MS (ESI−) M/Z 393 (M−H)−.

Sources & evidence

ORD record
ord-d8e51263b2d44b249fb513fcb18dba5b
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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