Benzeneacetic acid, 4-bromo- → HCID 70976173, compound

HRID 535576Notes

Reaction equation

HRID 535576 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[Br:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27](O)=[O:28])=[CH:22][CH:21]=1>>[Br:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:28])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 74654Benzeneacetic acid, 4-bromo-HCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976173HCID 70976173, compound

Procedure

The product of Example 1B and 2-(4-bromophenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.30 (dd, J=7.9, 1.3 Hz, 1H), 8.03 (dd, J=8.1, 1.3 Hz, 1H), 7.97-8.01 (m, 1H), 7.91 (td, J=7.5, 1.3 Hz, 1H), 7.54-7.56 (m, 2H), 7.33-7.36 (m, 2H), 3.78-3.83 (m, 4H), 3.65 (s, 2H), 3.08-3.13 (m, 4H); MS (ESI−) M/Z 441 (M−H)−.

Sources & evidence

ORD record
ord-042360e1480842c2a922aaf8eb5c1e8e
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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