(4-Nitrophenyl)acetic acid → HCID 70976303, compound

HRID 535578Notes

Reaction equation

HRID 535578 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[N+:19]([C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29](O)=[O:30])=[CH:24][CH:23]=1)([O-:21])=[O:20]>>[N:12]1([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:18])[N:2]([NH:1][C:29](=[O:30])[CH2:28][C:25]3[CH:24]=[CH:23][C:22]([N+:19]([O-:21])=[O:20])=[CH:27][CH:26]=3)[N:11]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 4661(4-Nitrophenyl)acetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976303HCID 70976303, compound

Procedure

The product of Example 1B and 2-(4-nitrophenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/D2O) δ 8.30 (d, J=7.4, 1H), 8.27-8.21 (m, 2H), 8.04 (d, J=7.8, 1H), 8.02-7.96 (m, 1H), 7.94-7.88 (m, 1H), 7.67 (d, J=8.6, 2H), 3.84-3.81 (m, 4H), 3.70 (s, 2H), 3.11-3.07 (m, 4H); MS (ESI−) M/Z 408 (M−H)−.

Sources & evidence

ORD record
ord-d8dd630a5cb74c77904caed6160953ca
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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