Felbinac → HCID 70976129, compound

HRID 535579Notes

Reaction equation

HRID 535579 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[C:19]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:24]=[CH:23][C:22]([CH2:25][C:26](O)=[O:27])=[CH:21][CH:20]=1>>[C:19]1([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:20]=[CH:21][C:22]([CH2:25][C:26]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:27])=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 3332FelbinacHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976129HCID 70976129, compound

Procedure

The product of Example 1B and 2-(biphenyl-4-yl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.32 (d, J=7.9 Hz, 1H), 8.04 (d, J=8.0 Hz, 1H), 7.97-8.01 (m, 1H), 7.89-7.93 (m, 1H), 7.56-7.69 (m, 4H), 7.47-7.50 (m, 4H), 7.38 (t, J=7.4 Hz, 1H), 3.78-3.84 (m, 4H), 3.72 (s, 2H), 3.09-3.11 (m, 4H); MS (ESI+) M/Z 441 (M+H)+.

Sources & evidence

ORD record
ord-fd825b326c304fd49984b88bfa8ea6b8
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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