HuagongsheHuagongshe Chemistry Print Report · For research reference only
Mesitylacetic acid → N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]-2-(2,4,6-trimethylphenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Mesitylacetic acid | HCID 78123 | — |
| Reactant | 2-amino-4-morpholinophthalazin-1(2H)-one | HCID 70976104 | — |
| Product | N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]-2-(2,4,6-trimethylphenyl)acetamide | HCID 70976029 | — |
Reaction Steps
The product of Example 1B and 2-(2,4,6-trimethylphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.30 (d, J=7.3 Hz, 1H), 8.02 (d, J=8.0 Hz, 1H), 7.96-8.00 (m, 1H), 7.88-7.92 (m, 1H), 6.84-6.85 (bs, 2H), 3.77-3.85 (m, 4H), 3.66 (s, 2H), 3.08-3.13 (m, 4H), 2.31 (s, 6H), 2.21 (s, 3H); MS (ESI+) M/Z 407 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859549B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-fcceb814cb684bf2979726fc7da9ff01 |
| Source note | uspto-grants-2014_10 |